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Epidemiology beyond its limits
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DOI：10.1126/sciadv.abn3328.png)
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摘要
En 中文
In 1995, journalist Gary Taubes published an article in Science titled Epidemiology faces its limits, which questioned the utility of nonrandomized epidemiologic research and has since been cited more than 1000 times. He highlighted numerous examples of research topics he viewed as having questionable merit. Studies have since accumulated for these associations. We systematically evaluated current evidence of 53 example associations discussed in the article. Approximately one-quarter of those presented as doubtful are now widely viewed as causal based on current evaluations of the public health consensus. They include associations between alcohol consumption and breast cancer, residential radon exposure and lung cancer, and the use of tanning devices and melanoma. This history should inform current debates about the reproducibility of epidemiologic research results.
Keyword:
BREAST-CANCER RISK
DOSE-RESPONSE METAANALYSIS
ORAL-CONTRACEPTIVE USE
DIETARY-FAT INTAKE
BODY-MASS INDEX
POOLED ANALYSIS
MENDELIAN-RANDOMIZATION
LUNG-CANCER
CHILDHOOD LEUKEMIA
OVARIAN-CANCER
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期刊
IF:
12.5
论文数:
2.0W
被引数:
18.1W
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