Epigenetics and Exercise

doi:10.1016/j.tem.2019.06.002

2019-09-01

PRE

Sean L. McGee *

Mark Hargreaves *

DOI：10.1016/j.tem.2019.06.002

原文链接

原文求助

摘要

En 中文

Epigenetics can be defined as 'the structural adaptation of chromosomal regions so as to register, signal, or perpetuate altered activity states.' Increased transcription of key regulatory, metabolic, and myogenic genes is an early response to exercise and is important in mediating subsequent adaptations in skeletal muscle. DNA hypomethylation and histone hyperacetylation are emerging as important crucial events for increased transcription. The complex interactions between multiple epigenetic modifications and their regulation by metabolic changes and signaling events during exercise, with implications for enhanced understanding of the acute and chronic adaptations to exercise, are questions for further investigation.

Keyword:

ACTIVATED PROTEIN-KINASE

HUMAN SKELETAL-MUSCLE

ACETYL-COA CARBOXYLASE

DNA METHYLATION

HISTONE H3

MESSENGER-RNA

METABOLISM

AMPK

REVEALS

PHOSPHORYLATION

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Trends in Endocrinology and Metabolism

IF:

12.6

论文数:

2.8K

被引数:

1.3W

机构

Deakin University

学者数:

2.0W

论文数: 2.1W

被引数: 2.8W

university of melbourne

学者数:

5.7W

论文数: 5.4W

被引数: 69

引用论文

Effect of erythromycin on carbamazepine kinetics 红霉素对卡马西平动力学的影响

Clinical Pharmacology and Therapeutics

IF0

1983-04-01

PREAI

Yan Yan Wong; Thomas M Ludden; Rodney D Bell

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle

CELL METABOLISM

IF30.9

2012-03-01

732

OAAI

Barres, Romain; Yan, Jie; Egan, Brendan; Treebak, Jonas Thue; Rasmussen, Morten; Fritz, Tomas; Caidahl, Kenneth; Krook, Anna; O'Gorman, Donal J.; Zierath, Juleen R.

Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

TRENDS IN ENDOCRINOLOGY AND METABOLISM

IF12.6

2018-09-01

OAAI

Ye, Cunqi; Tu, Benjamin P.

Lack of Sir2 increases acetate consumption and decreases extracellular pro-aging factors

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

IF0

2013-03-01

OAAI

Nadia Casatta; Alessandra Porro; Ivan Orlandi; Luca Brambilla; Marina Vai

Adaptation Improves Neural Coding Efficiency Despite Increasing Correlations in Variability

The Journal of Neuroscience

IF0

2013-01-30

OAAI

Mehdi Adibi; James S. McDonald; Colin W. G. Clifford; Ehsan Arabzadeh

Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14 组蛋白H3中丝氨酸10的磷酸化在体外和体内与赖氨酸14的Gcn5-mediated乙酰化功能相关

MOLECULAR CELL

IF16.6

2000-06-01

568

OAAI

Lo, WS; Trievel, RC; Rojas, JR; Duggan, L; Hsu, JY; Allis, CD; Marmorstein, R; Berger, SL

A novel role for lipid droplets in the organismal antibacterial response

ELIFE

IF0

2012-11-13

119

OAAI

Anand, Preetha; Cermelli, Silvia; Li, Zhihuan; Kassan, Adam; Bosch, Marta; Sigua, Robilyn; Huang, Lan; Ouellette, Andre J.; Pol, Albert; Welte, Michael A.; Gross, Steven P.

p300 is not required for metabolic adaptation to endurance exercise training

FASEB JOURNAL

IF4.2

2015-12-28

OAAI

LaBarge, Samuel A.; Migdal, Christopher W.; Buckner, Elisa H.; Okuno, Hiroshi; Gertsman, Ilya; Stocks, Ben; Barshop, Bruce A.; Nalbandian, Sarah R.; Philp, Andrew; McCurdy, Carrie E.; Schenk, Simon

BOLD: The Boulder Optimal Logic Design system

[1989] Proceedings of the Twenty-Second Annual Hawaii International Conference on System Sciences. Volume 1: Architecture Track

IF0

2024-10-23

PREAI

G. Hachtel; M. Lightner; K. Bartlett; D. Bostwick; R. Jacoby; P. Moceyunas; C. Morrison; X. Du; E. Schwarz

Role of the Thymus in Neonatal Life

Nature

IF0

1962-07-01

PREAI

DELPHINE M. V. PARROTT; JUNE EAST

查看更多内容