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Epilepsy biomarkers
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DOI：10.1111/epi.12299.png)
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摘要
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A biomarker is defined as an objectively measured characteristic of a normal or pathologic biologic process. Identification and proper validation of biomarkers of epileptogenesis (the development of epilepsy) and ictogenesis (the propensity to generate spontaneous seizures) might predict the development of an epilepsy condition; identify the presence and severity of tissue capable of generating spontaneous seizures; measure progression after the condition is established; and determine pharmacoresistance. Such biomarkers could be used to create animal models for more cost-effective screening of potential antiepileptogenic and antiseizure drugs and devices, and to reduce the cost of clinical trials by enriching the trial population, and acting as surrogate markers to shorten trial duration. The objectives of the biomarker subgroup for the London Workshop were to define approaches for identifying possible biomarkers for these purposes. Research to identify reliable biomarkers may also reveal underlying mechanisms that could serve as therapeutic targets for the development of new antiepileptogenic and antiseizure compounds.
Keyword:
Biomarkers
Surrogate markers
Epileptogenesis
Ictogenesis
期刊
IF:
6.6
论文数:
1.1W
被引数:
3.2W
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引用论文
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BioResources
OAAI
BioResourcesIF0
OAAI分享收藏Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009癫痫发作和癫痫组织的修订术语和概念: ILAE分类和术语委员会的报告，2005至2009EPILEPSIA
EPILEPSIAIF6.6
PREAI
分享收藏Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsyEPILEPSIA
EPILEPSIAIF6.6
PREAI
分享收藏
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