Epileptogenesis

doi:10.1101/cshperspect.a022822

Epileptogenesis

2015-09-18

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DOI：10.1101/cshperspect.a022822

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Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis. However, thanks to active research, a large number of animal models have become available for search of molecular mechanisms of epileptogenesis. The first glimpses of treatment targets and biomarkers that could be developed to become useful in clinic are in sight. However, the heterogeneity of the epilepsy condition, and the dynamics of molecular changes over the course of epileptogenesis remain as challenges to overcome.

Keyword:

TEMPORAL-LOBE EPILEPSY

TRAUMATIC BRAIN-INJURY

DENTATE GRANULE CELLS

SPONTANEOUS RECURRENT SEIZURES

CONTROLLED CORTICAL IMPACT

INDUCED STATUS EPILEPTICUS

FLUID PERCUSSION INJURY

MIDDLE CEREBRAL-ARTERY

SPRAGUE-DAWLEY RATS

TERM VIDEO-EEG

Epileptogenesis

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