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Erythema multiforme
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DOI：10.1016/j.eclinm.2024.102909.png)
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Erythema multiforme is an inflammatory skin and mucosal disease mainly related to infectious agents such as Herpes simplex virus, Mycoplasma pneumoniae, though it can also be idiopathic . The characteristic skin lesions are typical or atypical acral raised target lesions. The oral mucosa can be affected, alone or in combination with other mucosal/cutaneous sites, sometimes causing extreme pain, severely impacting food intake, and warranting hospitalization. A comprehensive understanding of erythema multiforme clinical characteristics, triggering agents, and differential diagnosis including Stevens-Johnson syndrome/Toxic Epidermal Necrolysis, is crucial to conduct proper workup and management. Mycoplasma pneumoniae infection should be immediately ruled out because of the need of antibiotics. The cornerstone of management is symptomatic treatment and will be detailed in this review as well as the etiologic treatment. Lastly, the management of persistent or recurrent erythema multiforme can be challenging, especially when antivirals fail to prevent a relapse, but breakthrough treatments have been reported successful in this difficult-to-treat subset of patients. Funding The Funding was provided by the University of Sherbrooke Faculty of Medicine and Health Sciences. Copyright (c) 2024 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
Keyword:
Erythema multiforme
Mycoplasma pneumoniae
Herpes simplex virus
期刊
IF:
10
论文数:
4.2K
被引数:
1.9W
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More than Mycoplasma-induced rash and mucositis: The potential role of Mycoplasma pneumoniae in Stevens-Johnson syndrome/toxic epidermal necrolysis超过支原体引起的皮疹和粘膜炎: 肺炎支原体在史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症中的潜在作用
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