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Evolving Always-Critical Networks
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DOI：10.3390/life10030022.png)
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摘要
En 中文
Living beings share several common features at the molecular level, but there are very few large-scale operating principles which hold for all (or almost all) organisms. However, biology is subject to a deluge of data, and as such, general concepts such as this would be extremely valuable. One interesting candidate is the criticality principle, which claims that biological evolution favors those dynamical regimes that are intermediaries between ordered and disordered states (i.e., at the edge of chaos). The reasons why this should be the case and experimental evidence are briefly discussed, observing that gene regulatory networks are indeed often found on, or close to, the critical boundaries. Therefore, assuming that criticality provides an edge, it is important to ascertain whether systems that are critical can further evolve while remaining critical. In order to explore the possibility of achieving such always-critical evolution, we resort to simulated evolution, by suitably modifying a genetic algorithm in such a way that the newly-generated individuals are constrained to be critical. It is then shown that these modified genetic algorithms can actually develop critical gene regulatory networks with two interesting (and quite different) features of biological significance, involving, in one case, the average gene activation values and, in the other case, the response to perturbations. These two cases suggest that it is often possible to evolve networks with interesting properties without losing the advantages of criticality. The evolved networks also show some interesting features which are discussed.
Keyword:
evolving systems
criticality
edge of chaos
gene regulatory networks
Boolean models
genetic algorithms
random Boolean networks
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3.4
论文数:
1.1W
被引数:
2.4W
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