.png){kind=icon}
返回
Exact analytical loop closure in proteins using polynomial equations
.png){kind=icon}
PRE
AI
DOI：10.1002/(SICI)1096-987X(199906)20:8<819::AID-JCC8>3.0.CO;2-Y.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Loop closure in proteins has been studied actively for over 25 years. Using spherical geometry and polynomial equations, several loop-closure problems in proteins are solved exactly by reducing them to the determination of the real roots of a polynomial. Loops of seven, flight, and nine atoms are treated explicitly, including the tripeptide and disulfide-bonded loop-closure problems. The number of valid loop closures can be evaluated by the method of Sturm chains, which counts the number of real roots of a polynomial. Longer loops can be treated by three methods: by sampling enough dihedral angles to reduce the problem to a soluble loop-closure problem; by applying the loop-closure algorithm hierarchically; or by decimating the chain into independently moving rigid elements that can be reconnected using loop-closure algorithms. Applications of the methods to docking, homology modeling and NMR problems are discussed. (C) 1999 John Wiley & Sons, Inc.
Keyword:
loop closure
ring closure
rigid geometry
spherical geometry
resultants
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.8
论文数:
7.1K
被引数:
6.1W
机构
暂无机构信息
引用论文
Empirical models of the normalized radar cross section of monostatic freshwater clutter单基地淡水杂波的归一化雷达散射截面的经验模型
.png){kind=icon}
PREAI
分享收藏
分享收藏
查看更多内容