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Exiting the Golgi complex

delete2008-04-01
delete449
PRE
AI
M
Maria Antonietta De Matteis *
A
Alberto Luini
DOI：10.1038/nrm2378delete
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摘要

摘要

En 中文
The composition and identity of cell organelles are dictated by the flux of lipids and proteins that they receive and lose through cytosolic exchange and membrane trafficking. The trans-Golgi network (TGN) is a major sorting centre for cell lipids and proteins at the crossroads of the endocytic and exocytic pathways; it has a complex dynamic structure composed of a network of tubular membranes that generate pleiomorphic carriers targeted to different destinations. Live-cell imaging combined with three-dimensional tomography has recently provided the temporal and topographical framework that allows the assembly of the numerous molecular machineries so far implicated in sorting and trafficking at the TGN.
Keyword:
PLASMA-MEMBRANE TRANSPORT
MYOSIN-II
BASOLATERAL TRANSPORT
ACTIN DYNAMICS
RECYCLING ENDOSOMES
MEDIATED REGULATION
MULTIPLE ACTIVITIES
VESICLE TRANSPORT
APICAL TRANSPORT
ANCHORED PROTEIN
AI总结

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对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

N
Nature Reviews Molecular Cell Biology
IF:
90.2
论文数:
4.1K
被引数:
8.6W

机构

I
istituto di ricerche farmacologiche mario negri irccs
学者数:
50
论文数: 17
被引数: 316
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