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Exosome-Encapsulated CuPt-S Hybrid Nanoclusters: Triple Enzyme Activities for Cuproptosis-Enhanced Low-Dose Radiotherapy
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DOI：10.1016/j.colsurfb.2026.115796.png)
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Abstract
En 中文
• Innovative synthesis of EM-CPS nanoclusters for inducing cuproptosis via low-dose RT. • Sulfur hybridization generates abundant ion pairs while enhancing triple enzymatic activity. • Exosome coating improves biocompatibility, tumor accumulation, and reduces off-target cytotoxicity. • In vivo studies demonstrate potent tumor suppression, robust immune activation effect, and excellent biosafty.
Keywords:
Cuproptosis
Low-dose radiotherapy
Exosome-encapsulated nanoclusters
Triple enzymatic activity
Tumor suppression
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5.6
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