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Exploring potential toxicological pathways of triclosan in human ovarian dysfunction via integrated network toxicology and experimental validation
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DOI：10.1016/j.ecoenv.2026.120617.png)
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Abstract
En 中文
• Network toxicology suggests TCS induces ovarian toxicity via apoptosis and inflammation. • Triclosan shows strong binding affinity to AKT1, EGFR, TNF, IL6, and CASP3. • Transcriptomics suggests TCS disrupts apoptosis and inflammatory pathways in granulosa cells. • TCS promoted apoptosis and inflammatory cytokines in SVOG and KGN granulosa cell lines.
Keywords:
Triclosan
Ovarian dysfunction
Granulosa cells
Network toxicology
Molecular docking
Transcriptomics
Journal
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6.1
Papers:
1.8W
Citations:
6.9W
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