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Exploring the efficacy evaluation model for androgenic alopecia using hair organoids: Transcending conventional hair research
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DOI：10.1016/j.jdermsci.2026.04.001.png)
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Abstract
En 中文
• Hair organoids derived from ES cells successfully mimic scalp and hair follicle characteristics. • Androgenic alopecia was modeled using DHT, validating organoids as an evaluation tool. • SOYACT, effective in vitro and ex vivo, showed aligned efficacy in the organoid system. • Minoxidil and SOYACT restored hair follicles and biomarkers reduced by DHT treatment. • Hair organoids present a novel, alternative platform for preclinical anti-hair loss testing.
Keywords:
Hair organoids
Androgenic alopecia
DHT
SOYACT
Minoxidil
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