Expression quantitative trait loci: present and future

Alexandra C. Nica

doi:10.1098/rstb.2012.0362

2013-06-19

418

Alexandra C. Nica

Emmanouil T. Dermitzakis *

DOI：10.1098/rstb.2012.0362

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摘要

En 中文

The last few years have seen the development of large efforts for the analysis of genome function, especially in the context of genome variation. One of the most prominent directions has been the extensive set of studies on expression quantitative trait loci (eQTLs), namely, the discovery of genetic variants that explain variation in gene expression levels. Such studies have offered promise not just for the characterization of functional sequence variation but also for the understanding of basic processes of gene regulation and interpretation of genome-wide association studies. In this review, we discuss some of the key directions of eQTL research and its implications.

Keyword:

expression quantitative trait loci

regulation

genetics

期刊

Philosophical Transactions of the Royal Society B-Biological Sciences

IF:

4.7

论文数:

8.7K

被引数:

5.6W

机构

university of geneva

学者数:

3.6W

论文数: 2.9W

被引数: 35

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