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Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis
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DOI：10.1016/j.devcel.2022.02.011.png)
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Organ morphogenesis involves dynamic changes of tissue properties while cells adapt to their mechanical environment through mechanosensitive pathways. How mechanical cues influence cell behaviors during morphogenesis remains unclear. Here, we studied the formation of the zebrafish atrioventricular canal (AVC) where cardiac valves develop. We show that the AVC forms within a zone of tissue convergence associated with the increased activation of the actomyosin meshwork and cell-orientation changes. We demonstrate that tissue convergence occurs with a reduction of cell volume triggered by mechanical forces and the mechanosensitive channel TRPP2/TRPV4. Finally, we show that the extracellular matrix component hyaluronic acid controls cell volume changes. Together, our data suggest that multiple force-sensitive signaling pathways converge to modulate cell volume. We conclude that cell volume reduction is a key cellular feature activated by mechanotransduction during cardiovascular morphogenesis. This work further identifies how mechanical forces and extracellular matrix influence tissue remodeling in developing organs.
Keyword:
NUCLEAR VOLUME
GOLGI-COMPLEX
BLOOD-FLOW
TISSUE
MECHANOTRANSDUCTION
DIFFERENTIATION
DISRUPTION
EXPRESSION
MATRIX
IMAGE
期刊
IF:
8.7
论文数:
6.3K
被引数:
3.4W
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