.png){kind=icon}
.png){kind=icon}
Return
Extrapolation of lung pharmacokinetics of bedaquiline across species using physiologically-based pharmacokinetic modelling
.png){kind=icon}
OA
AI
E
O
A
DOI：10.1002/bcp.70163.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
BeBedaquiline (BDQ) is a first-in-class diarylquinoline (DARQ) and a potent anti-tuberculosis drug, vital in combating multi-drug resistant tuberculosis (TB). Understanding its lung pharmacokinetics (PK) across species is crucial for effective clinical translation. This study aimed to extrapolate BDQ’s lung PK from preclinical species to humans, focusing on healthy and TB-infected lung tissue.
Keywords:
bedaquiline
dose selection
extrapolation
physiologically-based pharmacokinetic modelling
tissue pharmacokinetics
tuberculosis
Journal
IF:
3
Papers:
8.5K
Citations:
1.8W
Organization
Cited Papers