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Facile construction of bis-spiro-enol oxazolidines via a modular tandem strategy
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DOI：10.1016/j.tetlet.2026.156008.png)
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Abstract
En 中文
An efficient strategy has been successfully developed for the synthesis of symmetrical bis-spiroenol oxazolidines. This reaction process involves a two-step tandem condensation of readily accessible amino alcohols, 1,3-cyclic diketones, and aldehydes, utilizing formic acid as the promoter. The protocol features excellent substrate generality and tolerates a wide range of aromatic, aliphatic, and heterocyclic aldehydes, as well as various amino alcohols and cyclic diketones, to produce the target compounds in moderate to excellent yields. This method provides facile access to a new class of functional molecular architectures that combine a rigid spirocyclic framework, an oxazolidine heterocycle and tautomerizable enol units. The well-defined, three-dimensional structures of these compounds present promising platforms for investigating structure-property relationships and exploring potential applications in medicinal chemistry and materials science.
Keywords:
Oxazolidine
Spirocyclic compound
Enol
Tandem
Journal
T
IF:
1.5
Papers:
148
Citations:
4.2W
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