Facile four-component domino cyclocondensation for the synthesis of 7-amino-pyrimidine-2,4(1H,3H)-dione derivatives using DES-supported silica catalyst in green solvent and evaluation of antimicrobial activity

2026-08-11

PRE

Anushka Servesh

Santhosh Govindaraju *

Sumaiya Tabassum

S. Lokesh Kumar

DOI：10.1016/j.molliq.2026.129844

Original

Original request for help

Save

Abstract

En 中文

• One-pot four-component domino cyclocondensation for pyrimidine-2,4-diones. • DES-functionalized silica acts as a recyclable heterogeneous catalytic system. • 2-MeTHF-mediated protocol under ambient conditions with high atom economy. • Rapid conversion (≤15 min) with excellent yields (up to 94%) and selectivity. • Antimicrobial screening reveals promising bioactivity of synthesized scaffolds.

Keywords:

7-Amino-pyrimidine-2,4(1H,3H)-diones

One-pot

Heterogeneous catalysis

Multicomponent reactions

Green solvents

Antibacterial studies

Facile four-component domino cyclocondensation for the synthesis of 7-amino-pyrimidine-2,4(1H,3H)-dione derivatives using DES-supported silica catalyst in green solvent and evaluation of antimicrobial activity

Abstract

Journal

Organization

Cited Papers

Citing Papers