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Fibrinolysis in a nutshell

delete2025-08-04
delete0
PRE
AI
A
Anton Ilich
N
Nigel S. Key *
DOI：10.1111/bjh.70063delete
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摘要

摘要

En 中文
纤维蛋白溶解是纤维蛋白（血凝块的主要蛋白质成分）被酶促降解的过程。该过程中的关键事件是部分降解的纤维蛋白上形成组织型纤溶酶原激活剂（tPA）-纤溶酶原复合物，这导致纤溶酶原转化为纤溶酶，后者随后通过蛋白酶解作用消化纤维蛋白。该系统受到多种抑制剂和凝块结构的严格调控。纤维蛋白溶解系统的许多成分具有超越纤维蛋白溶解的作用（例如在衰老、基础代谢、炎症和癌症中），但这些内容本文将不予详述。
Keyword:
fibrin
fibrinolysis
plasmin
tranexamic acid

期刊

British Journal of Haematology 封面图
British Journal of Haematology
IF:
3.8
论文数:
1.2K
被引数:
2.6W

机构

U
unc blood research center
学者数:
2
论文数: 1
被引数: 0
引用论文

引用论文

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Primary hyperfibrinolysis: Facts and fancies
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Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation
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