.png){kind=icon}
返回
Fighting microbial pathogens by integrating host ecosystem interactions and evolution
.png){kind=icon}
OA
AI
DOI：10.1002/bies.202000272.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Successful therapies to combat microbial diseases and cancers require incorporating ecological and evolutionary principles. Drawing upon the fields of ecology and evolutionary biology, we present a systems-based approach in which host and disease-causing factors are considered as part of a complex network of interactions, analogous to studies of classical ecosystems. Centering this approach around empirical examples of disease treatment, we present evidence that successful therapies invariably engage multiple interactions with other components of the host ecosystem. Many of these factors interact nonlinearly to yield synergistic benefits and curative outcomes. We argue that these synergies and nonlinear feedbacks must be leveraged to improve the study of pathogenesis in situ and to develop more effective therapies. An eco-evolutionary systems perspective has surprising and important consequences, and we use it to articulate areas of high research priority for improving treatment strategies.
Keyword:
cancer
infectious disease
nonlinear dynamics
resistance
systems approach
therapies
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
2.7
论文数:
4.7K
被引数:
1.0W
机构
引用论文
分享收藏Cancers attributable to infections among adults with HIV in the United States美国成人HIV感染引起的癌症.png)
AIDSOAAI
AIDSIF3.1
OAAI分享收藏
查看更多内容