.png){kind=icon}
返回
Fingolimod effects on left ventricular function in multiple sclerosis
.png){kind=icon}
PRE
AI
DOI：10.1177/1352458515587753.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Background: Cardiovascular side effects such as bradycardia and atrioventricular block were observed during the early clinical trials of fingolimod in multiple sclerosis, and one cardiovascular- linked death has been reported in the post-marketing period. Objective: To investigate the medium-term effects of fingolimod on heart function in order to obtain further insights into its cardiac safety profile. Methods: The study involved 53 patients starting treatment with fingolimod 0.5 mg daily and 25 patients treated with natalizumab 300 mg monthly. Cardiac function was assessed by means of echocardiography at baseline (T0), and after one (T1), six (T6), and (in the case of the fingolimod group) 12 months (T12). Results: Mean left ventricular ejection fraction significantly decreased and end-systolic volume increased from T0 to T1 (p=0.005) and T6 (p=0.0001) in the fingolimod but not the natalizumab group, although a slight increase was observed at T12. A similar decrease in ejection fraction was also observed after six months in nine patients switched from natalizumab to fingolimod. Conclusion: Fingolimod significantly reduces left ventricular systolic function in MS patients. This effect has no clinical consequences in subjects without previous cardiac disorders, but suggests that more caution is required in patients with current or previous heart failure.
Keyword:
Fingolimod
multiple sclerosis
left ventricular systolic function
drug safety
drug side effects
ventricular ejection fraction
cardiotoxicity
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
5
论文数:
5.4K
被引数:
1.4W
机构
引用论文
.png){kind=icon}
A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis口服芬戈莫德治疗复发性多发性硬化症的安慰剂对照试验
OAAI
OAAI分享收藏
查看更多内容