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Flanked Block-Interchange Distance on Strings

delete2024-03-01
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PRE
AI
T
Tiantian Li
姜海涛 封面图
姜海涛 (Haitao Jiang)
B
Binhai Zhu
王
王路生 (Lusheng Wang) *
朱
朱大铭 (Daming Zhu) *
DOI:10.1109/TCBB.2024.3351440delete
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摘要

摘要

En 中文
Rearrangement sorting problems impact profoundly in measuring genome similarities and tracing historic scenarios of species. However, recent studies on genome rearrangement mechanisms disclosed a statistically significant evidence, repeats are situated at the ends of rearrangement relevant segments and stay unchanged before and after rearrangements.To reflect the principle behind this evidence, we propose flanked block-interchange, an operation on strings that exchanges two substrings flanked by identical left and right symbols in a string. The flanked block-interchange distance problem is formulated as finding a shortest sequence of flanked block-interchanges to transform a string into the other. We propose a sufficient and necessary condition for deciding whether two strings can be transformed into each other by flanked block-interchanges. This condition is linear time verifiable. Under this condition for two strings, we present a $\text{4}\,k$4k-approximation algorithm for the flanked block-interchange distance problem where each symbol occurs at most $k$k times in a string and a polynomial algorithm for this problem where each symbol occurs at most twice in a string. We show that the problem of flanked block-interchange distance is NP-hard at last.
Keyword:
Algorithm
complexity
flanked block-interchange
genome
rearrangement
string

期刊

I
IEEE-ACM Transactions on Computational Biology and Bioinformatics
IF:
3.4
论文数:
3.3K
被引数:
6.4K

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montana state university bozeman
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shandong university
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Montana State University System
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5.8K
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