Flicking the switch for B-cell development

Ashley P. Ng

doi:10.1101/gad.353397.125

2026-02-01

PRE

Ashley P. Ng

Stephen L. Nutt *

DOI：10.1101/gad.353397.125

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B细胞的产生对于功能性免疫系统的形成至关重要。这一过程依赖于少数转录因子的协同活动，它们部分通过改变淋巴祖细胞的染色质景观，从而允许按顺序表达B细胞发育所必需的基因。在《Genes & Development》本期的文章中，Tingvall-Gustafsson及其同事（doi:10.1101/gad.353002.125）研究了这些转录调控因子与发育中淋巴细胞染色质状态的相互作用，其分辨率达到单细胞水平。他们确定了发生这种表观遗传重编程的罕见祖细胞群体，该群体能够同时抑制谱系不相容基因的表达并激活B细胞程序。

Keyword:

B-lymphocytes

epigenetics

transcription

期刊

GENES & DEVELOPMENT

IF:

7.7

论文数:

被引数:

机构

walter & eliza hall institute

学者数:

3.7K

论文数: 2.7K

被引数: 6

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