.png){kind=icon}
返回
Fluctuation-driven morphological patterning: An unconventional approach to morphogenesis
.png){kind=icon}
OA
AI
DOI：10.1103/PhysRevResearch.6.043027.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Recent experimental investigations into Hydra regeneration revealed a remarkable phenomenon: the morphological transformation of a tissue fragment from the incipient spherical configuration to a tubelike structure-the hallmark of a mature Hydra-has the dynamical characteristics of a first-order phase transition, with calcium field fluctuations within the tissue playing an essential role. This morphological transition was shown to be generated by activation over a barrier within an effective morphological potential that underlies morphogenesis. Inspired by this intriguing insight, we propose an unconventional mechanism where stochastic fluctuations drive the emergence of morphological patterns. Thus, the inherent fluctuations determine the nature of the dynamics and are not incidental noise in the background of the otherwise deterministic dynamics. Instead, they play an important role as a driving force that defines the attributes of the pattern formation dynamics and the nature of the transition itself. Here, we present a simple model that captures the essence of this mechanism for morphological pattern formation. Specifically, we consider a one-dimensional tissue arranged as a closed contour embedded in a two-dimensional space, where the local curvature of the contour is coupled to a non-negative scalar field. An effective temperature parameter regulates the strength of the fluctuations in the system. The tissue exhibits fluctuations near a circular shape at sufficiently low coupling strengths, but as the coupling strength exceeds some critical value, the circular state becomes unstable. The nature of the transition to the new state, namely whether it is a first-order-like or second-order-like transition, depends on the effective temperature and the effective cutoff on the wavelength of the spatial variations in the system. The former sets the level of noise, while the latter determines the height of the potential barrier between the initial circular state and the final deformed state of the tissue. It is also found that entropic barriers separate various metastable states of the system.
Keyword:
INTERSTITIAL CELL-MIGRATION
DIFFUSION
期刊
IF:
4.2
论文数:
7.6K
被引数:
2.7W
机构
引用论文
Characterization of Large-Area AlGaInP/Mirror/Si Light-Emitting Diodes Fabricated by Wafer Bonding
.png){kind=icon}
PREAI
分享收藏Position and Attitude Control of Deep-Space Spacecraft Formation Flying Via Virtual Structure and Theta-D Technique基于虚拟结构和Theta-D技术的深空航天器编队飞行的位置和姿态控制
PREAI
分享收藏
Electrospun Polyvinyl Alcohol/Nanodiamond Composite Scaffolds: Morphological, Structural, and Biological Analysis静电纺丝聚乙烯醇/纳米金刚石复合支架: 形态，结构和生物学分析
PREAI
分享收藏
查看更多内容