.png){kind=icon}
返回
Fluorescence activation with switchable oxazines
.png){kind=icon}
PRE
AI
DOI：10.1039/c8cc03094d.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The identification of operating principles to activate fluorescence under the influence of external stimulations is essential to enable the implementation of imaging strategies requiring the spatiotemporal control of emission. In this context, our laboratories designed mechanisms to switch fluorescence with either light or pH based on the unique photochemical and photophysical properties of either photoresponsive or halochromic oxazines respectively. These heterocycles can be connected covalently to fluorescent chromophores and opened with either light or pH to impose a significant bathochromic shift on the main absorption of the emissive appendage. Such a spectral change allows the selective excitation of the resulting species to activate bright fluorescence with infinite contrast and spatiotemporal control. Indeed, these mechanisms for fluorescence activation enable the acquisition of images with subdiffraction resolution, the selective signaling of cancer cells and the monitoring of translocating species in real time. Thus, our structural designs for fluorescence switching under external control can evolve into invaluable probes for the implementation of bioimaging strategies that would be impossible to perform with conventional fluorophores.
Keyword:
PHOTOREMOVABLE PROTECTING GROUPS
PHOTOACTIVATABLE FLUOROPHORES
REACTION-MECHANISMS
FOLATE RECEPTOR
CANCER
PROBES
PHOTOCHROMISM
CHEMISTRY
DESIGN
LIGHT
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.2
论文数:
5.9W
被引数:
16.5W
机构
引用论文
.png){kind=icon}
分享收藏
分享收藏Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications叶酸受体在卵巢癌治疗中的作用: 证据、机制和临床意义
PREAI
分享收藏
查看更多内容