.png){kind=icon}
返回
Force-Mediating Magnetic Nanoparticles to Engineer Neuronal Cell Function
.png){kind=icon}
OA
AI
DOI：10.3389/fnins.2018.00299.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Cellular processes likemembrane deformation, cellmigration, and transport of organelles are sensitive to mechanical forces. Technically, these cellular processes can be manipulated through operating forces at a spatial precision in the range of nanometers up to a few micrometers through chaperoning force-mediating nanoparticles in electrical, magnetic, or optical field gradients. But which force-mediating tool is more suitable to manipulate cell migration, and which, to manipulate cell signaling? We review here the differences in forces sensation to control and engineer cellular processes inside and outside the cell, with a special focus on neuronal cells. In addition, we discuss technical details and limitations of different force-mediating approaches and highlight recent advancements of nanomagnetics in cell organization, communication, signaling, and intracellular trafficking. Finally, we give suggestions about how force-mediating nanoparticles can be used to our advantage in next-generation neurotherapeutic devices.
Keyword:
intracellular forces
nanomagnetics
nanoparticles
neurons
cell guidance
cell communication
cell polarity
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.2
论文数:
1.6W
被引数:
5.3W
机构
引用论文
Biophysical Tools for Cellular and Subcellular Mechanical Actuation of Cell Signaling.png)
BIOPHYSICAL JOURNALOAAI
BIOPHYSICAL JOURNALIF3.1
OAAI分享收藏Fully exposed edge/corner active sites in Fe substituted-Ni(OH)2 tube-in-tube arrays for efficient electrocatalytic oxygen evolution在Fe取代的-Ni(OH)2管中管阵列中完全暴露的边缘/角活性位点，用于有效的电催化析氧
PREAI
分享收藏Tensile force-dependent neurite elicitation via anti-β1 integrin antibody-coated magnetic beadsBIOPHYSICAL JOURNALOAAI
BIOPHYSICAL JOURNALIF3.1
OAAI分享收藏Nav channel mechanosensitivity: Activation and inactivation accelerate reversibly with stretchBIOPHYSICAL JOURNALOAAI
BIOPHYSICAL JOURNALIF3.1
OAAI分享收藏Programmed Self-Assembly of a Biochemical and Magnetic Scaffold to Trigger and Manipulate Microtubule StructuresSCIENTIFIC REPORTSOAAI
SCIENTIFIC REPORTSIF3.9
OAAI分享收藏
查看更多内容