.png){kind=icon}
返回
Formation and function of multiciliated cells
.png){kind=icon}
OA
AI
DOI：10.1083/jcb.202307150.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Lyu et al. summarize the current knowledge of multiciliogenesis by which the respiratory tract, brain ventricles, and reproductive tracts of vertebrates form multiple motile cilia for tissue homeostasis. In vertebrates, multiciliated cells (MCCs) are terminally differentiated cells that line the airway tracts, brain ventricles, and reproductive ducts. Each MCC contains dozens to hundreds of motile cilia that beat in a synchronized manner to drive fluid flow across epithelia, the dysfunction of which is associated with a group of human diseases referred to as motile ciliopathies, such as primary cilia dyskinesia. Given the dynamic and complex process of multiciliogenesis, the biological events essential for forming multiple motile cilia are comparatively unelucidated. Thanks to advancements in genetic tools, omics technologies, and structural biology, significant progress has been achieved in the past decade in understanding the molecular mechanism underlying the regulation of multiple motile cilia formation. In this review, we discuss recent studies with ex vivo culture MCC and animal models, summarize current knowledge of multiciliogenesis, and particularly highlight recent advances and their implications.
Keyword:
DYNEIN REGULATORY COMPLEX
CHOROID-PLEXUS FUNCTION
HUMAN AIRWAY EPITHELIA
BASAL BODIES
MOTILE CILIA
CENTRAL-PAIR
INTRAFLAGELLAR TRANSPORT
CENTRIOLE AMPLIFICATION
STEM-CELLS
SIGNALING CONTROLS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
6.4
论文数:
1.2W
被引数:
5.7W
机构
引用论文
Comparison between electrophysiologic studies and ambulatory monitoring in patients with syncope
PREAI
分享收藏Mapping the Gene That Encodes Phosphatidylinositol-Specific Phospholipase C-γ2 in the Human and the Mouse.png)
Genomics
GenomicsIF0
PREAI
分享收藏
Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient miceDEVELOPMENTOAAI
DEVELOPMENTIF3.6
OAAI分享收藏Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cellsNATURE GENETICSOAAI
NATURE GENETICSIF31.8
OAAI分享收藏Cell-cycle-regulated expression of STIL controls centriole number in human cellsSTIL的细胞周期调节表达控制人细胞的中心粒数OAAI
OAAI分享收藏
查看更多内容