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Four new ent-abietane diterpenoids from Euphorbia fischeriana and their bioactivity
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DOI：10.1016/j.tetlet.2026.156064.png)
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Abstract
En 中文
Four new ent-abietane diterpenoids 1-4 were isolated from the methanol extract of the roots of Euphorbia fischeriana. Their structures were elucidated using HRESIMS, NMR spectroscopy, and X-ray diffraction. The biological activities of these compounds were evaluated through cytotoxicity assay against three human breast cancer cell lines (MDA-MB-231, MDA-MB-468, and MCF-7) and anti-inflammatory assay using lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, respectively. Among them, compound 2 displayed moderate cytotoxicity against MDA-MB-468, with an IC50 of 11.7 mu M, and compound 3 exhibited the most potent antiinflammatory effect, inhibiting NO production with an IC50 of 14.5 mu M.
Keywords:
Euphorbia
Euphorbia fischeriana
Diterpenoid
Anti-inflammatory effect
Cytotoxicity
Journal
T
IF:
1.5
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148
Citations:
4.2W
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