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From Rigid Membranes to Flexible Textiles: Porous Glass Fibers as Carriers for Sustained Drug Release
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DOI：10.1111/jace.70934.png)
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Abstract
En 中文
Flexible carriers that combine high drug loading and favorable drug compatibilities with a wider spectrum of more defined release properties are needed to broaden the scope of transdermal drug delivery systems (TDDS). Here, we transform rigid porous glass into flexible textile architectures by drawing SiO2-B2O3-Na2O fibers (50 and 150 µm in diameter), inducing phase separation through controlled thermal treatment, and generating porosity via selective leaching. Differential scanning calorimetry revealed glass transition temperatures (Tg) to be 40°C–50°C higher for fibers than for bulk glass, necessitating higher treatment temperatures in order to obtain comparable mesoporosity. After leaching, all materials exhibited ∼20 nm pores. Woven textiles were fabricated using non-porous S2 warp threads and porous glass weft fibers, yielding 2 × 2 cm2 fabrics with preserved flexibility. Using anastrozole as a model drug, in vitro release experiments in a stirred container showed geometry-dependent drug release. Membranes delivered the payload within ∼10 min. Alkaline-leached textiles displayed a similar burst profile but markedly higher loading capacities. Acid-leached textiles containing residual colloidal silica showed a gradual release over 24 h, reflecting increased tortuosity. Collectively, these results demonstrate that porous glass fiber textiles unite macroscopic flexibility with tunable pore architecture and drug transport, offering an inorganic platform that spans rapid to sustained release regimes and complements polymer-based TDDS.
Keywords:
glass fiber
glass fiber textile
porous glass
sustained release
transdermal drug delivery systems
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