From study design to executable code: automating target trial emulation with large language models

Hanjae Kim, BS

doi:10.1093/jamiaopen/ooag131

2026-07-09

DOI：10.1093/jamiaopen/ooag131

原文链接

原文求助

摘要

En 中文

将目标试验模拟（TTE）研究作为标准化的、可复现的分析工作流程实施，技术要求高。我们开发了基于Strategus的文本引导健康研究估计与规范引擎（THESEUS），该引擎利用大型语言模型（LLMs）将自由文本的研究描述转化为结构化的分析规范和Strategus R脚本，在Observational Health Data Sciences and Informatics（OHDSI）生态系统内运行。

期刊

JAMIA Open

IF:

3.4

论文数:

379

被引数:

1.7K

机构

Yonsei University College of Medicine

学者数:

2.0K

论文数: 656

被引数: 1

引用论文

Risks for Anaphylaxis With Intravenous Iron Formulations A Retrospective Cohort Study

ANNALS OF INTERNAL MEDICINE

IF15.2

2022-05-01

PREAI

Dave, Chintan, V; Brittenham, Gary M.; Carson, Jeffrey L.; Setoguchi, Soko

Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers: Multidatabase Target Trial Emulation Studies 血管紧张素转换酶抑制剂与血管紧张素受体阻滞剂的比较有效性：多数据库目标试验模拟研究

HYPERTENSION

IF8.2

2025-12-01

OAAI

Xie, Chao; Chen, Ruixuan; Zhou, Shiyu; Lin, Yaduan; Liu, Jiao; Su, Licong; Pang, Mingzhen; Guo, Zhixin; Luo, Fan; Chen, Linjiang; Kong, Yaozhong; Nie, Sheng

Comparative effectiveness of valproic acid in different serum concentrations for maintenance treatment of bipolar disorder: A retrospective cohort study using target trial emulation framework

ECLINICALMEDICINE

IF10

2022-12-01

OAAI

Chen, Yang-Chieh Brian; Liang, Chih-Sung; Wang, Liang-Jen; Hung, Kuo-Chuan; Carvalho, Andre F.; Solmi, Marco; Vieta, Eduard; Tseng, Ping-Tao; Lin, Pao -Yen; Tu, Yu-Kang; Hsu, Chih-Wei; Lai, Edward Chia-Cheng

Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study

BMJ-BRITISH MEDICAL JOURNAL

IF42.7

2019-05-29

153

OAAI

Xie, Yan; Bowe, Benjamin; Yan, Yan; Xian, Hong; Li, Tingting; Al-Aly, Ziyad

Cardiovascular Outcomes in Patients Initiating First-Line Treatment of Type 2 Diabetes With Sodium-Glucose Cotransporter-2 Inhibitors Versus Metformin A Cohort Study

ANNALS OF INTERNAL MEDICINE

IF15.2

2022-07-01

PREAI

Shin, Hojin; Schneeweiss, Sebastian; Glynn, Robert J.; Patorno, Elisabetta

Understanding variation in the results of real-world evidence studies that seem to address the same question

JOURNAL OF CLINICAL EPIDEMIOLOGY

IF5.2

2022-11-01

OAAI

Wang, Shirley V.; Sreedhara, Sushama Kattinakere; Bessette, Lily G.; Schneeweiss, Sebastian

Comparative estimation of the effects of antihypertensive medications on schizophrenia occurrence: a multinational observational cohort study

BMC PSYCHIATRY

IF3.6

2024-02-16

OAAI

Lee, Dong Yun; Kim, Chungsoo; Kim, Jiwoo; Yun, Jeongwon; Lee, Yujin; Chui, Celine Sze Ling; Son, Sang Joon; Park, Rae Woong; You, Seng Chan

Large Language Models for Automating Clinical Trial Criteria Conversion to Observational Medical Outcomes Partnership Common Data Model Queries: Validation and Evaluation Study Lee, K.H.; Jang, S.; Kim, G.J.; Park, S.; Kim, D.; Kwon, O.J.; Lee, J.-H.; Kim, Y.-H. 大型语言模型在自动化临床试验标准转换为观察性医学结果合作组织常用数据模型查询中的应用：验证与评估研究。JMIR Med. Inform. 2025, 13, e71252. [Google Scholar] [CrossRef]

JMIR Medical Informatics

IF0

PREAI

Lee,Kye Hwa; Jang,Sujung; Kim,Grace Juyun; Park,Sukyoung; Kim,Doeun; Kwon,Oh Jin; Lee,Jae-Ho; Kim,Young-Hak

Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM 二线抗高血糖药物对心血管结局的疗效比较——LEGEND-T2DM跨国联盟分析的成果

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

IF22.3

2024-09-01

PREAI

Dhingra, Lovedeep Singh; Thangaraj, Phyllis M.; Camargos, Aline Pedroso; Bu, Fan; Ding, Xiyu; Nishimura, Akihiko; Anand, Tara V.; Arshad, Faaizah; Blacketer, Clair; Chattopadhyay, Shounak; Cook, Michael; Dorr, David A.; Duarte-Salles, Talita; DuVall, Scott L.; Falconer, Thomas; French, Tina E.; Hanchrow, Elizabeth E.; Kaur, Guneet; Lau, Wallis C. Y.; Li, Jing; Li, Kelly; Liu, Yuntian; Lu, Yuan; Man, Kenneth K. C.; Matheny, Michael E.; Mathioudakis, Nestoras; McLeggon, Jody-Ann; McLemore, Michael F.; Minty, Evan; Morales, Daniel R.; Nagy, Paul; Ostropolets, Anna; Pistillo, Andrea; Reyes, Carlen; Richter, Lauren; Ross, Joseph S.; Ruan, Elise; Seager, Sarah L.; Simon, Katherine R.; Viernes, Benjamin; Yang, Jianxiao; Yin, Can; Zhou, Jin J.; Ryan, Patrick B.; Schuemie, Martijn J.; Krumholz, Harlan M.; Hripcsak, George; Suchard, Marc A.

Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation

CRITICAL CARE

IF9.3

2022-05-24

OAAI

Reijnders, Tom D. Y.; Peters-Sengers, Hessel; van Vught, Lonneke A.; Uhel, Fabrice; Bonten, Marc J. M.; Cremer, Olaf L.; Schultz, Marcus J.; Stuiver, Martijn M.; van der Poll, Tom

查看更多内容