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Full closed loop open-source algorithm performance comparison in pigs with diabetes

delete2021-05-01
delete9
delete
OA
AI
R
Rayhan Lal
C
Caitlin L. Maikawa
D
Dana Lewis
S
Sam W. Baker
A
Anton A. A. Smith
G
Gillie A. Roth
E
Emily C. Gale
L
Lyndsay M. Stapleton
J
Joseph L. Mann
A
Anthony C. Yu
S
Santiago Correa
A
Abigail K. Grosskopf
C
Celine S. Liong
C
Catherine M. Meis
D
Doreen Chan
J
Joseph P. Garner
D
David M. Maahs
B
Bruce A. Buckingham
E
Eric A. Appel *
DOI：10.1002/ctm2.387delete
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摘要

摘要

En 中文
Understanding how automated insulin delivery (AID) algorithm features impact glucose control under full closed loop delivery represents a critical step toward reducing patient burden by eliminating the need for carbohydrate entries at mealtimes. Here, we use a pig model of diabetes to compare AndroidAPS and Loop open-source AID systems without meal announcements. Overall time-in-range (70-180 mg/dl) for AndroidAPS was 58% +/- 5%, while time-in-range for Loop was 35% +/- 5%. The effect of the algorithms on time-in-range differed between meals and overnight. During the overnight monitoring period, pigs had an average time-in-range of 90% +/- 7% when on AndroidAPS compared to 22% +/- 8% on Loop. Time-in-hypoglycemia also differed significantly during the lunch meal, whereby pigs running AndroidAPS spent an average of 1.4% (+0.4/-0.8)% in hypoglycemia compared to 10% (+3/-6)% for those using Loop. As algorithm design for closed loop systems continues to develop, the strategies employed in the OpenAPS algorithm (known as oref1) as implemented in AndroidAPS for unannounced meals may result in a better overall control for full closed loop systems.
Keyword:
automated insulin delivery
diabetes
open‐ source closed loop
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期刊

Clinical and Translational Medicine 封面图
Clinical and Translational Medicine
IF:
6.8
论文数:
2.7K
被引数:
9.6K

机构

S
Stanford University
学者数:
9.6W
论文数: 8.2W
被引数: 17.0W
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