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Ganoderic acid A accelerates osteoporotic fracture healing by promoting osteogenic differentiation via estrogen receptor alpha binding

delete2026-07-23
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OA
AI
K
Kecheng Tang
Y
Yiru Chen
Y
Yan Yu
Z
Zhizhen Huang
H
Hang Zhang
Y
Yun Tian
M
Min Li
印悦 (Yue Yin)
杨宝学 cover
杨宝学 (Baoxue Yang) *
B
Bingchuan Liu *
DOI:10.1016/j.jot.2026.101173delete
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Abstract

Abstract

En 中文
Ganoderic acid A (GAA), a natural triterpenoid derived from the fungal species Ganoderma lucidum which is known for its medicinal properties, is well recognized for its anti-inflammatory, anti-aging, kidney-protective, and hepatoprotective properties. However, its role in osteoporotic fracture (OF) healing remains unclear.This study aims to explore the pharmacological effects of GAA on OF healing and to clarify its underlying mechanisms.
Keywords:
Bone formation
Bone resorption
Estrogen receptor alpha
Ganoderic acid A
Osteogenic differentiation
Osteoporotic fractures
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Journal

Journal of Orthopaedic Translation cover
Journal of Orthopaedic Translation
IF:
7.8
Papers:
1.1K
Citations:
4.1K

Organization

P
peking university third hospital
Scholars:
547
Papers: 133
Citations: 0
P
peking university
Scholars:
11.5W
Papers: 8.6W
Citations: 146
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