GATA-3 localization shapes lymphocyte function

Philippe Saikali

doi:10.1016/j.celrep.2026.116925

2026-02-04

DOI：10.1016/j.celrep.2026.116925

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摘要

En 中文

• GATA-3 accumulates in the nucleus of progenitor and type 2 but not type 1 Th cells and ILCs • Reprogramming of Th1 and Th2 cells reverses GATA-3 localization, thus altering gene expression • Importin-β mediates the import of GATA-3 into the nucleus • Short half-life of nuclear GATA-3 requires its continuous import to maintain Th2 cell function

Keyword:

transcription factor

GATA-3

importin-β

importazole

nuclear import

intracellular compartmentalization

T helper cell

innate lymphoid cell

LCMV

Th1 and Th2 cell reprogramming

CP: immunology

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Cell Reports

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6.9

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1.7W

被引数:

10.2W

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experimental immunology and osteoarthritis research

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Institute of Medical Immunology

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infectiology and rheumatology

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Max Planck Institute for Infection Biology

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