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GATA simple sequence repeats function as enhancer blocker boundaries
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DOI：10.1038/ncomms2872.png)
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Simple sequence repeats (SSRs) account for similar to 3% of the human genome, but their functional significance still remains unclear. One of the prominent SSRs the GATA tetranucleotide repeat has preferentially accumulated in complex organisms. GATA repeats are particularly enriched on the human Y chromosome, and their non-random distribution and exclusive association with genes expressed during early development indicate their role in coordinated gene regulation. Here we show that GATA repeats have enhancer blocker activity in Drosophila and human cells. This enhancer blocker activity is seen in transgenic as well as native context of the enhancers at various developmental stages. These findings ascribe functional significance to SSRs and offer an explanation as to why SSRs, especially GATA, may have accumulated in complex organisms.
Keyword:
DROSOPHILA BITHORAX COMPLEX
CHROMATIN DOMAIN BOUNDARY
GENOME-WIDE ANALYSIS
PROMOTER COMMUNICATION
ATTACHMENT REGIONS
GENETIC-VARIATION
INSULATOR
PROTEIN
ELEMENT
DNA
期刊
IF:
15.7
论文数:
9.4W
被引数:
91.2W
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引用论文
Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification.png)
NATURE GENETICS
NATURE GENETICSIF31.8
PREAI
分享收藏The enhancer-blocking activity of the Fab-7 boundary from the Drosophila bithorax complex requires GAGA-factor-binding sitesGENETICS
OAAI
GENETICSIF5.1
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