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Gene order alignment on trees with multiOrthoAlign
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DOI：10.1186/1471-2164-15-S6-S5.png)
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摘要
En 中文
We relate the comparison of gene orders to an alignment problem. Our evolutionary model accounts for both rearrangement and content-modifying events. We present a heuristic based on dynamic programming for the inference of the median of three genomes and apply it in a phylogenetic framework. multiOrthoAlign is shown accurate on simulated and real datasets, and shown to significantly improve the running-time of DupLoCut, an almost exact algorithm based on linear programming, developed recently for the same problem.
Keyword:
SORTING SIGNED PERMUTATIONS
POLYNOMIAL ALGORITHM
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期刊
IF:
3.7
论文数:
1.9W
被引数:
5.2W
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引用论文
LAGAN and Multi-LAGAN: Efficient tools for large-scale multiple alignment of genomic DNALAGAN和Multi-LAGAN: 基因组DNA大规模多重比对的有效工具.png)
GENOME RESEARCHOAAI
GENOME RESEARCHIF5.5
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