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Genome editing
DOI:10.1038/s41598-022-24850-x.png)
摘要
En 中文
Recent advances in genome editing technologies have redefined our ability to probe and precisely edit the human genome and epigenome in vitro and in vivo. More specifically, RNA-guided CRISPR/Cas systems have revolutionized the field due to their simplicity in design and adaptability across biological systems. This Collection highlights results in CRISPR/Cas technology that increase the efficiency of precision genome editing, and allow genetic manipulation in model systems traditionally intractable to site-directed gene modification.
Keyword:
ONE-STEP GENERATION
DNA
CRISPR/CAS
GENES
CELLS
AI总结
对已上传原文的论文进行重点信息的提取,主要内容包括:简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.9
论文数:
28.0W
被引数:
83.5W
机构
引用论文
Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC使用合成CRISPR-Cas9-based HDAC进行基因座特异性组蛋白脱乙酰化
NATURE COMMUNICATIONS
IF15.7
Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9
NATURE COMMUNICATIONS
IF15.7
Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
NATURE COMMUNICATIONS
IF15.7
Dual-sgRNA CRISPR/Cas9 knockout of PD-L1 in human U87 glioblastoma tumor cells inhibits proliferation, invasion, and tumor-associated macrophage polarization
SCIENTIFIC REPORTS
IF3.9

