Genome-wide characterization of the interleukin gene family in Nile tilapia (Oreochromis niloticus) spleen: identification, expression dynamics, and regulatory mechanism during Streptococcus agalactiae infection

Zhang Wang

doi:10.1016/j.fsi.2025.111072

Genome-wide characterization of the interleukin gene family in Nile tilapia (Oreochromis niloticus) spleen: identification, expression dynamics, and regulatory mechanism during Streptococcus agalactiae infection

2025-12-12

0

PRE

AI

Z

Zhang Wang

S

Shaowei Huang

L

Liu Hong

C

Chenglin Tang

Z

Zhigang Liu

J

Jianmeng Cao

M

Miao Wang

M

Mengmeng Yi

X

Xiaoli Ke *

DOI：10.1016/j.fsi.2025.111072

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• Genome-wide identification of IL genes in Nile Tilapia. • IL family was expanded via tandem duplication and whole-genome duplication in tilapia. • Six ILs showed differential expression in spleen after S. agalactiae infection. • Specifically, IL-17A pathway activated the expression of IL-6, IL-8, and IL-8L in spleen cells. • And the promoter of IL-17D underwent demethylation in spleens after S. agalactiae treatment.

Genome-wide characterization of the interleukin gene family in Nile tilapia (Oreochromis niloticus) spleen: identification, expression dynamics, and regulatory mechanism during Streptococcus agalactiae infection

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