Genotype Imputation

doi:10.1146/annurev.genom.9.081307.164242

2009-09-01

949

DOI：10.1146/annurev.genom.9.081307.164242

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摘要

En 中文

Genotype imputation is now an essential tool in the analysis of genome-wide association scans. This technique allows geneticists to accurately evaluate the evidence for association at genetic markers that are not directly genotyped. Genotype imputation is particularly useful for combining results across studies that rely on different genotyping platforms but also increases the power of individual scans. Here, we review the history and theoretical underpinnings of the technique. To illustrate performance of the approach, we summarize results from several gene mapping studies. Finally, we preview the role of genotype imputation in an era when whole genome resequencing is becoming increasingly common.

Keyword:

whole genome association study

resequencing

association study

HapMap

1000 Genomes Project

期刊

Annual Review of Genetics

IF:

8.6

论文数:

912

被引数:

7.7K

机构

University of Michigan

学者数:

6.4W

论文数: 5.3W

被引数: 124

university of michigan system

学者数:

9.1W

论文数: 8.6W

被引数: 133

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