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Geometrically adaptive hydrogel attenuates osteoarthritis via metabolic reprogramming and defect sealing

delete2026-07-27
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PRE
AI
J
Jinlong Zhang
X
Xinmeng Zha
X
Xiangxiu Wang
T
Tianjie Bao
C
Chengqi He
K
Kunpeng Cui *
L
Lin Yang *
DOI：10.1016/j.biomaterials.2026.124482delete
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Abstract

Abstract

En 中文
• Injectable dual-network hydrogel autonomously seals irregular defects. • Material reprograms chondrocyte metabolism via PI3K/Akt signaling. • Restores anabolic homeostasis without exogenous growth factors. • Single injection restores the osteochondral unit in osteoarthritic rats.

Journal

Biomaterials cover
Biomaterials
IF:
12.9
Papers:
1.9W
Citations:
10.8W

Organization

S
sichuan university
Scholars:
11.5W
Papers: 7.6W
Citations: 100
U
University of Science and Technology of China
Scholars:
1.5W
Papers: 5.3K
Citations: 11.3W
Cited Papers

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