Geometry-controlled kinetics

doi:10.1038/NCHEM.622

2010-04-18

307

PRE

DOI：10.1038/NCHEM.622

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摘要

En 中文

It has long been appreciated that the transport properties of molecules can control reaction kinetics. This effect can be characterized by the time it takes a diffusing molecule to reach a target-the first-passage time (FPT). Determining the FPT distribution in realistic confined geometries has until now, however, seemed intractable. Here, we calculate this FPT distribution analytically and show that transport processes as varied as regular diffusion, anomalous diffusion, and diffusion in disordered media and fractals, fall into the same universality classes. Beyond the theoretical aspect, this result changes our views on standard reaction kinetics and we introduce the concept of 'geometry-controlled kinetics'. More precisely, we argue that geometry-and in particular the initial distance between reactants in 'compact' systems-can become a key parameter. These findings could help explain the crucial role that the spatial organization of genes has in transcription kinetics, and more generally the impact of geometry on diffusion-limited reactions.

Keyword:

CHICKEN ERYTHROCYTE NUCLEI

ANOMALOUS DIFFUSION

1ST-PASSAGE TIMES

RANDOM-WALKS

FRACTAL NATURE

DYNAMICS

CHROMATIN

FLUORESCENCE

ORGANIZATION

MOLECULE

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期刊

Nature Chemistry

IF:

20.2

论文数:

4.4K

被引数:

4.8W

机构

centre national de la recherche scientifique (cnrs)

学者数:

24.5W

论文数: 18.2W

被引数: 279

Sorbonne Universite

学者数:

6.2W

论文数: 4.5W

被引数: 605

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