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Glioblastoma and resistance to radiotherapy: role of cancer stem cells subpopulations, hypoxia and therapeutic strategies
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DOI：10.1016/j.ctrv.2026.103198.png)
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Abstract
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• GSC subtypes and hypoxia collectively drive glioblastoma recurrence and radioresistance • Hypoxia maintains GSCs in a dedifferentiated state and induces phenotypic transitions (e.g., PMT, EMT-like). • Hadron therapy and HIF-targeted strategies offer promising approaches to overcome resistance.
Keywords:
Glioma stem cells
Hypoxia
Hypoxia-inducible factors
Glioblastoma
Radiotherapy
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