.png){kind=icon}
返回
Glomerular endothelial cell differentiation
.png){kind=icon}
OA
AI
DOI：10.1111/j.1523-1755.2005.00260.x.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Background. Glomerular endothelial cells differ from most other endothelial cells in that they are extraordinarily flattened and highly fenestrated. In this differentiated form, they allow formation of glomerular ultrafiltrate at a prodigious rate. Methods. Molecular processes that dictate the development and differentiation of glomerular endothelium are reviewed. Results. During glomerular development, angioblasts already present in the metanephric blastema well before any organized angio,genic sprouts invade the capillary cleft of developing nephrons at the comma and S-shape stages in response to chemotactic and guiding cues from primitive podocytes. The angioblasts then undergo homotypic aggregation into precapillary cords as yet devoid of a lumen. Lumen development then proceeds through the loss of superfluous endothelial cells by apoptosis as well as flattening of the remaining viable endothelial cells. The final step, fenestration, is critically dependent on appropriate stimuli, most notably vascular endothelial growth factor A (VEGF-A), from differentiated podocytes. Current evidence suggests that the fenestrae of fully differentiated glomerular endothelium can be lost within hours if the VEGF-A stimulus is removed, and that the glomerular endotheliosis, loss of glomerular filtration rate (GFR) and proteinuria observed in preeclampsia are due to the circulating inhibitor of VEGF-A, soluble VEGF receptor 1 (VEGFR-1). Conclusion. Differentiation of the glomerular endothelium is highly dependent on podocyte-derived stimuli and their loss leads to the derangements of glomerular function in preeclampsia.
Keyword:
VEGF
TGF-beta1
podocyte
preeclampsia
fenestration
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
12.6
论文数:
1.6W
被引数:
4.8W
机构
暂无机构信息
引用论文
分享收藏Differential patterning of ventral midline cells by axial mesoderm is regulated by BMP7 and chordin.png)
Development
OAAI
DevelopmentIF0
OAAI分享收藏
查看更多内容