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Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior

delete2026-03-25
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PRE
AI
J
Julien Guillard
J
Jessica Stradley
K
Kristof Turan
M
Marta Storl-Desmond
S
Shan C Lin
Y
Yi-Chia Huang
K
Kevin Muñoz Forti
C
Christopher R. Weber
S
Simon Schwörer *
DOI：10.1016/j.matbio.2026.03.004delete
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Abstract

Abstract

En 中文
• A proteomic atlas of the glutamine-regulated matrisome • Glutamine availability is coordinated with a gradient of ECM type and maturation • Collagen I is more sensitive to glutamine stress than collagen IV and fibronectin • Glutamine availability regulates the stiffness of fibroblast-derived ECM • Glutamine-derived αKG regulates ECM collagen I abundance and stiffness • Glutamine-dependent ECM stiffness restrains cancer cell growth
Keywords:
Glutamine
Extracellular matrix
Collagen I
ECM stiffness
Cancer cell growth

Journal

Matrix Biology cover
Matrix Biology
IF:
4.8
Papers:
109
Citations:
8.1K

Organization

U
University of Chicago
Scholars:
1.7K
Papers: 741
Citations: 6.7W
U
university of chicago
Scholars:
4.4W
Papers: 3.7W
Citations: 80
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