.png){kind=icon}
.png){kind=icon}
Return
Goyangamins A–C; Three Pairs of Enantiomeric 2(1H)-Quinolinone Alkaloid Dimers with Antisenescent Activity from Tetradium daniellii
.png){kind=icon}
PRE
AI
V
T
S
G
H
Y
W
DOI：10.1021/acs.jnatprod.6c00589.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Goyangamins A–C (1–3), three 2(1H)-quinolinone alkaloid dimers, were isolated from the roots of Tetradium daniellii. The structures of these dimers were elucidated by HRESIMS, 1D and 2D NMR spectroscopy, and ECD analysis. Compounds 1 and 2 feature an sp3–sp2 chiral axis, whereas compound 3 contains an sp2–sp2 chiral axis, giving rise to a pair of interconverting atropisomers. Variable-temperature NMR (VT NMR), in conjunction with computational potential energy surface (PES) scans, indicated that compounds 1–3 belong to class I atropisomers that can readily interconvert at room temperature. Compound 3 exhibited the most potent antisenescence activity, with an IC50 value of 7.8 ± 2.2 μM and showed a dual mode of action involving inhibition of senescence-associated secretory phenotype (SASP) markers (IL-6, IL-8, IL-1α, and IL-1β) and suppression of senescence-associated β-galactosidase (SA-β-gal) activity.
Journal
IF:
3.6
Papers:
1.2W
Citations:
2.9W
Organization
Cited Papers