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Grand Challenges for Industrializing Polyhydroxyalkanoates (PHAs)

delete2021-09-01
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PRE
AI
D
Dan Tan
王英 封面图
王英 (Ying Wang)
Y
Yi Tong
陈
陈国强 (Guo‐Qiang Chen) *
DOI:10.1016/j.tibtech.2020.11.010delete
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摘要

摘要

En 中文
Polyhydroxyalkanoates (PHAs) are a diverse family of sustainable bioplastics synthesized by various bacteria, but their high production cost and unstable material properties make them challenging to use in commercial applications. Current industrial biotechnology (CIB) employs conventional microbial chassis, leading to high production costs. However, next-generation industrial biotechnology (NGIB) approaches, based on fast-growing and contamination-resistant extremophilic Halomonas spp., allow stable continuous processing and thus economical production of PHAs with stable properties. Halomonas spp. designed and constructed using synthetic biology not only produce low-cost intracellular PHAs but also secrete extracellular soluble products for improved process economics. Nextgeneration industrial biotechnology is expected to reduce the bioproduction cost and process complexity, leading to successful commercial production of PHAs.
Keyword:
CELL-DENSITY CULTIVATION
ENHANCED PRODUCTION
PSEUDOMONAS-PUTIDA
HALOMONAS
POLY(3-HYDROXYBUTYRATE)
POLYHYDROXYBUTYRATE
BIOSYNTHESIS
STRAINS
GENES
TD01

期刊

Trends in Biotechnology 封面图
Trends in Biotechnology
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14.9
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3.8K
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xi'an jiaotong university
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tsinghua university
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beijing institute of technology
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