Great Tex-pectations

Grace Ward

doi:10.1093/jimmun/vkaf163

2025-10-01

PRE

Grace Ward

Ben Youngblood *

DOI：10.1093/jimmun/vkaf163

原文链接

原文求助

摘要

Keyword:

T-cell Exhaustion

PD-1

Immunotherapy

CD8 T cell

期刊

Journal of Immunology

IF:

3.4

论文数:

3.7W

被引数:

9.9W

机构

暂无机构信息

引用论文

Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells

JOURNAL OF IMMUNOLOGY

IF3.4

2013-07-15

156

OAAI

Youngblood, Ben; Noto, Alessandra; Porichis, Filippos; Akondy, Rama S.; Ndhlovu, Zaza M.; Austin, James W.; Bordi, Rebeka; Procopio, Francesco A.; Miura, Toshiyuki; Allen, Todd M.; Sidney, John; Sette, Alessandro; Walker, Bruce D.; Ahmed, Rafi; Boss, Jeremy M.; Sekaly, Rafick-Pierre; Kaufmann, Daniel E.

Restoring function in exhausted CD8 T cells during chronic viral infection 在慢性病毒感染过程中恢复耗尽的CD8 T细胞的功能

Nature

IF0

2005-12-28

PREAI

Daniel L. Barber; E. John Wherry; David Masopust; Baogong Zhu; James P. Allison; Arlene H. Sharpe; Gordon J. Freeman; Rafi Ahmed

CTLA-4 can function as a negative regulator of T cell activation

Immunity

IF0

1994-08-01

PREAI

Theresa L. Walunas; Deborah J. Lenschow; Christina Y. Bakker; Peter S. Linsley; Gordon J. Freeman; Jonathan M. Green; Craig B. Thompson; Jeffrey A. Bluestone

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade 耗尽的T细胞的表观遗传稳定性限制了通过PD-1阻断而恢复活力的持久性

Science

IF0

2016-12-02

OAAI

Kristen E. Pauken; Morgan A. Sammons; Pamela M. Odorizzi; Sasikanth Manne; Jernej Godec; Omar Khan; Adam M. Drake; Zeyu Chen; Debattama R. Sen; Makoto Kurachi; R. Anthony Barnitz; Caroline Bartman; Bertram Bengsch; Alexander C. Huang; Jason M. Schenkel; Golnaz Vahedi; W. Nicholas Haining; Shelley L. Berger; E. John Wherry

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

JOURNAL OF VIROLOGY

IF3.8

2003-04-15

1.6K

OAAI

Wherry, EJ; Blattman, JN; Murali-Krishna, K; van der Most, R; Ahmed, R

Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion

JOURNAL OF VIROLOGY

IF3.8

2016-10-01

OAAI

Ahn, Eunseon; Youngblood, Ben; Lee, Junghwa; Lee, Judong; Sarkar, Surojit; Ahmed, Rafi

Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2017-05-10

127

OAAI

Abdelsamed, Hossam A.; Moustaki, Ardiana; Fan, Yiping; Dogra, Pranay; Ghoneim, Hazem E.; Zebley, Caitlin C.; Triplett, Brandon M.; Sekaly, Rafick-Pierre; Youngblood, Ben

T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections T细胞因子1表达记忆样CD8 T细胞维持对慢性病毒感染的免疫反应

IMMUNITY

IF26.3

2016-08-01

760

OAAI

Utzschneider, Daniel T.; Charmoy, Melanie; Chennupati, Vijaykumar; Pousse, Laurene; Ferreira, Daniela Pais; Calderon-Copete, Sandra; Danilo, Maxime; Alfei, Francesca; Hofmann, Maike; Wieland, Dominik; Pradervand, Sylvain; Thimme, Robert; Zehn, Dietmar; Held, Werner

Origin and differentiation of human memory CD8 T cells after vaccination

Nature

IF0

2017-12-13

OAAI

Rama S. Akondy; Mark Fitch; Srilatha Edupuganti; Shu Yang; Haydn T. Kissick; Kelvin W. Li; Ben A. Youngblood; Hossam A. Abdelsamed; Donald J. McGuire; Kristen W. Cohen; Gabriela Alexe; Shashi Nagar; Megan M. McCausland; Satish Gupta; Pramila Tata; W. Nicholas Haining; M. Juliana McElrath; David Zhang; Bin Hu; William J. Greenleaf; Jorg J. Goronzy; Mark J. Mulligan; Marc Hellerstein; Rafi Ahmed

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy 定义PD-1治疗后提供增殖爆发的CD8 T细胞

Nature

IF0

2016-08-02

OAAI

Se Jin Im; Masao Hashimoto; Michael Y. Gerner; Junghwa Lee; Haydn T. Kissick; Matheus C. Burger; Qiang Shan; J. Scott Hale; Judong Lee; Tahseen H. Nasti; Arlene H. Sharpe; Gordon J. Freeman; Ronald N. Germain; Helder I. Nakaya; Hai-Hui Xue; Rafi Ahmed

查看更多内容