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Grief and bereavement: A pre-registered systematic review of neuroimaging studies
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DOI：10.1016/j.neubiorev.2025.106535.png)
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Abstract
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• Grief is a universal response to loss, however, its neural mechanisms are poorly understood, hindering effective interventions. • Our findings show disruptions in networks related to emotion regulation, reward processing, and cognitive control in grieving individuals. • We propose that these alterations may lead to dysregulation of both the neuroendocrine and immune systems. • Future research should prioritse longitudinal studies to track neural, endocrine, and immune trajectories of grief.
Keywords:
Grief
Bereavement
Functional MRI (fMRI)
Structural MRI
Autonomic nervous system
Neuroendocrine system
Immune system
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