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GSTT1 promotes stemness and FGFR inhibitor sensitivity in pancreatic cancer through regulation of CD133 (PROM1)
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DOI：10.1016/j.canlet.2026.218733.png)
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Abstract
En 中文
• Article Highlights • GSTT1 drives a stem-like program in pancreatic ductal adenocarcinoma. • GSTT1 promotes CD133 expression, self-renewal, and FGFR3 activation. • FGFR3 identifies a GSTT1-associated stem-like pancreatic cancer population. • GSTT1High tumors are selectively vulnerable to FGFR inhibition. • Patient-derived organoids validate FGFR inhibition as a therapeutic strategy.
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10.1
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