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Gut microbiota and metabolites in remodeling the tumor microenvironment and regulating immunotherapeutic efficacy in colorectal cancer

delete2026-07-07
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PRE
AI
M
Meichen Gu
Z
Zhuo Wang
F
Fuxue Huang
Y
Ying Li
Z
Zheng Liu
Z
Zhehao Huang *
P
Pengyu Chang *
DOI：10.1016/j.lfs.2026.124581delete
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Abstract

Abstract

En 中文
Immune checkpoint inhibitors (ICIs) benefit patients with mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC), but efficacy remains limited in proficient mismatch repair/microsatellite-stable (pMMR/MSS) tumors. This review evaluates how the gut microbiota and microbial metabolites influence CRC development, the tumor microenvironment, and immunotherapy responses, with emphasis on strategies for pMMR/MSS CRC.
Keywords:
Colorectal cancer
Gut microbiota
Metabolites
Tumor microenvironment
Immunotherapy

Journal

Life Sciences cover
Life Sciences
IF:
5.1
Papers:
1.7W
Citations:
4.7W

Organization

F
First Hospital of Jilin University
Scholars:
213
Papers: 72
Citations: 0
J
Jilin University
Scholars:
8.4W
Papers: 5.5W
Citations: 8.9K
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