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Gut microbiota–derived indole-3-propionic acid alleviates endoplasmic reticulum stress by regulating FMO2 in MASLD
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DOI：10.1097/HC9.0000000000000975.png)
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Abstract
En 中文
Metabolic dysfunction–associated steatotic liver disease (MASLD) has become a global health challenge for which there are currently no approved drugs. Indole-3-propionic acid (IPA), as one of the primary metabolites of gut microbiota, can influence the development of liver diseases through the gut-liver axis, but how it contributes to liver diseases remains unclear. The present study was conducted to explore the possible molecular mechanisms of IPA in the development of MASLD.
Keywords:
FMO2
gut microbiota metabolite
liver disease
oxidative stress
PERK/eIF2α/ATF4/CHOP
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