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H2BK5ac is required for the establishment of inflammatory potential in mouse embryonic stem cells following differentiation
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DOI：10.1016/j.celrep.2026.117850.png)
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Abstract
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• p300 and H2BK5ac levels increase concurrently during mouse ESC differentiation • The differentiation-induced upregulation of H2BK5ac is regulated by p300 and HDAC3 • H2BK5ac is enriched at inflammatory gene loci and is essential for their expression • H2BK5ac is required for the expression of pro-inflammatory cytokines
Keywords:
embryonic stem cells
inflammatory response
H2BK5ac
p300
HDAC3
CP: molecular biology
CP: immunology
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