Halogenases: structures and functions

Hannes Ludewig

doi:10.1016/j.sbi.2020.05.012

2020-12-01

PRE

DOI：10.1016/j.sbi.2020.05.012

原文链接

摘要

En 中文

Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.

Keyword:

CHLOROPEROXIDASE

HALOPEROXIDASE

DISCOVERY

PRODUCTS

FAMILY

SITE

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期刊

Current Opinion in Structural Biology

IF:

论文数:

3.8K

被引数:

1.5W

机构

University of St Andrews

学者数:

463

论文数: 241

被引数: 2.4K

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